Chronic fatigue syndrome (CFS) is one of the most intractable diseases and is\ncharacterized by severe central fatigue that impairs even daily activity. To date, the\npathophysiological mechanisms are uncertain and no therapies exist. Therefore, a proper animal\nmodel reflecting the clinical features of CFS is urgently required. We compared two CFS animal\nmodels most commonly used, by injection with lipopolysaccharide (LPS from Escherichia coli\nO111:B4) or polyinosinic: polycytidylic acid (poly I:C), along with bilateral adrenalectomy (ADX) as\nanother possible model. Both LPS- and poly I:C-injected mice dominantly showed depressive\nbehaviors, while ADX led to fatigue-like performances with high pain sensitivity. ..........................
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